Why the study?
Does propranolol reduce arrhythmias and myocardial injury via miR-1 downregulation in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction induced by coronary artery occlusion
Comparison
Propranolol vs Control (untreated/ischemic)
Design
Preclinical
Authors
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Does not change practice; hypothesis-generating for miR-1-targeted therapies in human ischemia.
Does propranolol reduce arrhythmias and myocardial injury via miR-1 downregulation in a rat model of myocardial infarction?
Propranolol exerts ischemic cardioprotection and antiarrhythmic effects partially by down-regulating arrhythmogenic miR-1 via the beta-adrenoceptor-cAMP-PKA signaling pathway.
Lu et al. (2009) studied this question.
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