Why the study?
Does sympathetic denervation reverse vertebrobasilar artery remodeling and lower blood pressure in spontaneously hypertensive rats?
Population
Pre-hypertensive spontaneously hypertensive rats, adult spontaneously hypertensive rats, and age-matched…
Comparison
Sympathetic denervation vs Age-matched normotensive Wistar rats
Design
Preclinical
Authors
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Sympathetic denervation leaves vertebrobasilar remodeling and pressure unchanged in SH rats; hypothesis-generating for independent parasympathetic contributions to brainstem perfusion.
Does sympathetic denervation reverse vertebrobasilar artery remodeling and lower blood pressure in spontaneously hypertensive rats?
Spontaneously hypertensive rats exhibit reduced parasympathetic innervation in vertebrobasilar arteries, suggesting compromised vasodilatory capacity that may contribute to brainstem hypoperfusion, independent of sympathetic nerve remodeling.
Roloff et al. (2018) studied this question.
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