Key result
Sympathetic denervation attenuated the development of hypertension and vascular changes in cerebral arteries of spontaneously hypertensive rats.
Why the study?
Does sympathetic denervation prevent structural changes in cerebral arteries of spontaneously hypertensive rats?
Population
28-week-old spontaneously hypertensive rats (SHR), stroke-prone SHR, and normotensive Wistar-Kyoto rats
Comparison
Sympathetic denervation induced with combined… vs Non-sympathectomized rats
Design
Preclinical
Follow-up
28 weeks
Authors
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Supports trophic sympathetic influence on cerebral remodeling in rat hypertension models; leaves open any clinical translation to humans.
Does sympathetic denervation prevent structural changes in cerebral arteries of spontaneously hypertensive rats?
Sympathetic nerves have a trophic influence upon the remodeling of cerebral arteries during the development of genetic hypertension in rats.
Mangiarua et al. (1992) studied Hypertension. Sympathetic denervation (antibody against nerve growth factor and guanethidine) vs. Non-sympathectomized rats and normotensive Wistar-Kyoto rats was evaluated on Morphometric measurement of structural changes in cerebral arteries. Sympathetic denervation attenuated the development of hypertension and vascular changes in cerebral arteries of spontaneously hypertensive rats.
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