Population
Conscious, hydrated rats (including sham-operated and bilaterally adrenalectomized models)
Comparison
Intracerebroventricular renin injections with or… vs IVT saline injections; sham-operated vs…
Design
Preclinical
Follow-up
6 hours
Authors
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Central renin natriuresis is mineralocorticoid-independent in rats; hypothesis-generating for human volume disorders and should not change practice.
The natriuretic effect of centrally administered renin is independent of mineralocorticoids and can occur in the absence of the adrenal glands.
Barbella et al. (1982) studied this question.
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