Relative contribution of correcting the diet and voluntary exercise to myocardial recovery in a two-hit murine model of heart failure with preserved ejection fraction

Most new mouse models of heart failure with preserved ejection fraction (HFpEF) are based on the combination of hypertension and metabolic alterations. These models provide a better approximation of the complexity of the processes involved in human HFpEF. Here, we show that the extent of reverse remodeling and myocardial recovery after stopping the causal stress in a mouse model depends on the biological sex, recovery duration, and diet correction.