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June 23, 2004Antimicrobial Agents and ChemotherapyOpen Access

Substitutions at Methionine 220 in the 14α-Sterol Demethylase (Cyp51A) of Aspergillus fumigatus Are Responsible for Resistance In Vitro to Azole Antifungal Drugs

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Authors

EMEmilia MelladoInstituto de Salud Carlos IIIGGGuillermo García‐EffrónNational University of the LittoralLALaura Alcázar‐FuoliInstituto de Salud Carlos III

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Mellado et al. (2004) studied this question.

synapsesocial.com/papers/6a893e83a4df84145ecafac4https://doi.org/10.1128/aac.48.7.2747-2750.2004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mutations in <i>Aspergillus fumigatus</i> Resulting in Reduced Susceptibility to Posaconazole Appear To Be Restricted to a Single Amino Acid in the Cytochrome P450 14α-Demethylase2003 · 189 citations
  2. 2A Three-Dimensional Model of Lanosterol 14α-Demethylase of Candida albicans and Its Interaction with Azole Antifungals2000 · 210 citations
  3. 3Inoculum Standardization for Antifungal Susceptibility Testing of Filamentous Fungi Pathogenic for Humans2001 · 143 citations
  4. 4Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans1999 · 96 citations
  5. 5Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA2001 · 95 citations