Why the study?
Only two randomized trials had evaluated metformin in nondiabetic heart failure, and neither assessed its role in reducing oxidative stress.
Does metformin improve oxidative stress and left ventricular geometry in nondiabetic patients with HFrEF?
Comparison
Metformin in addition to standard therapy vs standard of care alone
Design
Randomized controlled trial
Follow-up
6 months
Authors
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Metformin may improve antioxidant capacity and limit LV remodeling in nondiabetic HFrEF; extends sparse prior RCT data, supporting larger outcome trials.
Does metformin improve oxidative stress and left ventricular geometry in nondiabetic patients with HFrEF?
In nondiabetic patients with HFrEF, the addition of metformin to standard therapy for 6 months improved total antioxidant capacity and prevented an increase in left ventricular mass index.
Kamel et al. (2023) studied this question.
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