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December 5, 2007Journal of the American Society of Nephrology

Overexpression of Angiotensinogen Increases Tubular Apoptosis in Diabetes

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Population

Transgenic mice overexpressing angiotensinogen in renal proximal tubular cells with streptozotocin-induced…

Comparison

Insulin, RAS blockers, or hydralazine… vs Diabetic nontransgenic littermates; control cells

Design

Preclinical

Authors

FLFang LiuRutgers, The State University of New JerseyMBMarie-Luise BrezniceanuHôpital du Sacré-Cœur de MontréalCWChih‐Chang WeiUniversity of Alabama at Birmingham

Discussion

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Implication

Does not support changes in clinical RAS inhibitor use; hypothesis-generating for intrarenal synergy in diabetic tubular apoptosis.

Structured PICO

P
Population
Transgenic mice overexpressing angiotensinogen in renal proximal tubular cells (RPTC) with streptozotocin-induced diabetes, and rat immortalized RPTC overexpressing angiotensinogen
I
Intervention
Insulin, RAS blockers, or hydralazine (in vivo); high-glucose medium with/without insulin and/or RAS blockers (in vitro)
C
Comparator
Diabetic nontransgenic littermates (in vivo); control cells (in vitro)
O
Outcome
Blood pressure, albuminuria, RPTC apoptosis, and proapoptotic gene expressionsurrogate

Intrarenal RAS activation and high glucose act synergistically to increase tubular apoptosis in diabetes, independent of systemic hypertension.

Cite This Study

Liu et al. (2007) studied this question.

synapsesocial.com/papers/6a89426507adfc24ebcaf91ehttps://doi.org/10.1681/asn.2007010074
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations1993 · 310 citations
  2. 2Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule2004 · 113 citations
  3. 3Molecular biology and pathophysiology of the intrarenal renin-angiotensin system1989 · 37 citations
  4. 4The Kidney Androgen-regulated Protein Promoter Confers Renal Proximal Tubule Cell-specific and Highly Androgen-responsive Expression on the Human Angiotensinogen Gene in Transgenic Mice1997 · 160 citations
  5. 5Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system1995 · 86 citations