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June 19, 2023Frontiers in Cardiovascular MedicineOpen Access

Both pravastatin and atorvastatin prevented loss of endothelium-dependent relaxation and suppressed cytosolic reactive oxidative stress, but only pravastatin inhibited mitochondrial superoxide production, mitochondrial DNA damage, and expression of inflammatory markers.

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Why the study?

Statins during radiation therapy associate with reduced long-term cardiovascular risk, but the mechanisms protecting the vasculature from irradiation injury remain poorly understood.

Does pretreatment with pravastatin or atorvastatin prevent radiation-induced injury in cultured human endothelial cells and mice?

Population

Cultured human coronary and umbilical vein endothelial cells and mice subjected to head-and-neck irradiation

Comparison

Pravastatin vs atorvastatin pretreatment

Design

Preclinical in vitro and in vivo mechanistic study

Follow-up

24 and 240 h after irradiation

Authors

KAKarima Ait‐AissaLLLinette N. LengNLNathanial R. Lindsey

Discussion

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Overview

Hypothesis-generating for endothelial protection; leaves open clinical translation to reduced ASCVD after radiation.

Structured PICO

Does pretreatment with pravastatin or atorvastatin prevent radiation-induced injury in cultured human endothelial cells and mice?

P
Population
Cultured human coronary and umbilical vein endothelial cells irradiated with 4 Gy and mice subjected to 12 Gy head-and-neck irradiation
I
Intervention
Pretreatment with pravastatin (hydrophilic) or atorvastatin (lipophilic)
O
Outcome
Endothelial dysfunction, nitric oxide production, oxidative stress, and various mitochondrial phenotypes at 24 and 240 h after irradiationsurrogate

Pravastatin, a hydrophilic statin, may offer superior protection against radiation-induced mitochondrial injury and inflammation in endothelial cells compared to lipophilic atorvastatin.

Cite This Study

Ait‐Aissa et al. (2023) studied this question.

synapsesocial.com/papers/6a89448fb11dee029fbd4cf5https://doi.org/10.3389/fcvm.2023.1133315
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short-term statin treatment reduces, and long-term statin treatment abolishes chronic vascular injury by radiation therapy2023 · 4 citations
  2. 2Short‐Term Statin Treatment Reduces, and Long‐Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy2024 · 7 citations
  3. 3Pravastatin Limits Endothelial Activation after Irradiation and Decreases the Resulting Inflammatory and Thrombotic Responses2005 · 120 citations
  4. 4A multimodality assessment of the protective capacity of statin therapy in a mouse model of radiation cardiotoxicity2023 · 8 citations
  5. 5Protective Effect of Atorvastatin on Radiation-induced Vascular Endothelial Cell Injury In Vitro2010 · 37 citations