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November 14, 2023Radiotherapy and OncologyOpen Access

Atorvastatin prevented mild left ventricular systolic function impairment at 30-50 weeks and prolongation of cardiac conduction components at 10 and 30 weeks compared to radiation alone.

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Why the study?

Cardiotoxicity remains a common radiotherapy complication, and the efficacy of atorvastatin against late cardiac effects following clinically relevant partial-heart radiation exposure required evaluation.

Does atorvastatin prevent late radiation-induced cardiotoxicity in a mouse model of partial-heart radiation exposure?

Population

Female, 12-week old, C57BL/6j mice receiving an image-guided 16 Gy X-ray field to the heart base

Comparison

Atorvastatin vs no atorvastatin

Design

Preclinical animal study

Follow-up

50 weeks

Authors

GWGerard WallsMGMihaela GhitaBHBrian Herron

Discussion

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Member takes

Overview

Atorvastatin may protect against late radiation cardiotoxicity; leaves open confirmation in human trials before any practice change.

Structured PICO

Does atorvastatin prevent late radiation-induced cardiotoxicity in a mouse model of partial-heart radiation exposure?

P
Population
Female, 12-week old, C57BL/6j mice receiving an image-guided 16 Gy X-ray field to the base of the heart
I
Intervention
Atorvastatin from 1 week prior to irradiation until the end of the experiment (50 weeks)
C
Comparator
Radiation alone (RT control group) without atorvastatin
O
Outcome
Late effects of radiation exposure on systolic function, cardiac conduction, and atrial natriuretic peptide (ANP)surrogate

Atorvastatin prevents left ventricular systolic dysfunction and cardiac conduction perturbations following partial heart irradiation in a murine model, suggesting potential for cardioprotection during thoracic radiotherapy.

Cite This Study

Walls et al. (2023) studied this question.

synapsesocial.com/papers/6a6f70e66ceb2bbd16dfa9cahttps://doi.org/10.1016/j.radonc.2023.110004
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Also Consider

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