Why the study?
Does atorvastatin prevent radiation-induced injury in cultured human umbilical vein endothelial cells?
Population
Cultured human umbilical vein endothelial cells (HUVEC)
Comparison
Atorvastatin 10 µmol/ml for 10 minutes prior to… vs Irradiated HUVEC without atorvastatin treatment
Design
Preclinical
Follow-up
24 hours
Key result
Atorvastatin treatment of irradiated human umbilical vein endothelial cells decreased apoptosis by 6% and 16% at 2 Gy and 25 Gy, respectively, while up-regulating thrombomodulin and protein C.
Authors
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May protect irradiated HUVEC in vitro; hypothesis-generating and should not yet change practice.
Does atorvastatin prevent radiation-induced injury in cultured human umbilical vein endothelial cells?
Atorvastatin demonstrates protective effects against radiation-induced vascular endothelial cell injury in vitro by reducing apoptosis and enhancing the thrombomodulin-protein C pathway.
Ran et al. (2010) studied Radiation-induced vascular endothelial cell injury. Atorvastatin vs. Untreated irradiated cells was evaluated on Cell apoptosis, thrombomodulin (TM) expression, and protein C activation. Atorvastatin treatment of irradiated human umbilical vein endothelial cells decreased apoptosis by 6% and 16% at 2 Gy and 25 Gy, respectively, while up-regulating thrombomodulin and protein C.
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