Why the study?
Does adjusted-dose enoxaparin (peak anti-Xa 1.0-1.2 U/mL) safely prevent thrombosis in pregnant women with mechanical prosthetic heart valves?
Population
15 pregnant women with mechanical prosthetic heart valves (MPHV)
Design
Cohort
Follow-up
throughout pregnancy
Authors
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Supports adjusted-dose enoxaparin in this population but should not yet change practice; leaves open need for randomized confirmation.
Does adjusted-dose enoxaparin (peak anti-Xa 1.0-1.2 U/mL) safely prevent thrombosis in pregnant women with mechanical prosthetic heart valves?
Adjusted-dose enoxaparin targeting a peak anti-Xa of 1.0 to 1.2 U/mL appears safe and effective for thromboprophylaxis in pregnant women with mechanical prosthetic heart valves.
Saeed et al. (2010) studied this question.
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