This review highlights the detrimental cardiovascular effects of aldosterone and the clinical benefits of aldosterone-receptor antagonists in chronic heart failure.
Aldosterone has a variety of detrimental effects on the heart and vasculature and is increasingly recognized as an important target in chronic heart failure, as illustrated by the Randomized Aldactone Evaluation Study. In this article, the evidence supporting the cardiovascular effects of aldosterone in humans and the proven benefits of aldosterone-receptor antagonists in heart failure shall be discussed.
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Dawson et al. (2004) studied this question.
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