Why the study?
Does the addition of calmodulin and calcium reduce ouabain-sensitive ATPase activity in cardiac sarcolemmal membranes of SHR and WKY rats?
Does the addition of calmodulin and calcium reduce ouabain-sensitive ATPase activity in cardiac sarcolemmal membranes of SHR and WKY rats?
The calcium-dependent calmodulin reduction of ouabain-sensitive ATPase activity is greater in spontaneously hypertensive rats, suggesting an altered interaction that may play a role in hypertension pathogenesis.
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Suggests altered ATPase regulation in hypertensive rat models; hypothesis-generating for pathogenesis, with no clinical implications yet.
Calmodulin and calcium effects on cardiac ouabain-sensitive adenosine triphosphatase (ATPase) activity were studied in young spontaneously hypertensive rats (SHR) and in their normotensive control Wistar-Kyoto rats (WKY). Cardiac sarcolemmal membranes from SHR showed significantly higher ouabain-sensitive ATPase activity than membranes from WKY rats. This activity was unaffected by calmodulin or calcium alone. However, when both calmodulin and calcium were added, ouabain-sensitive activity was significantly reduced without changes in the total ATPase activity. The calcium-dependent calmodulin effect was dose-dependent and greater in SHR than in WKY membranes. An altered interaction between the calcium-calmodulin system and sodium handling by the plasma membrane in SHR may play a role in the pathogenesis of hypertension.
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Círillo et al. (1984) studied this question.
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