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August 22, 2026Scientific ReportsOpen Access

Patterns of multiple long-term conditions in patients presenting with breathlessness and their associations with adverse outcomes

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Authors

HSHarini SathanapallyKNKimon NtotsisDRDaniel Rojas

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Overview

Retrospective cohort study uncovers distinct multimorbidity patterns linked to healthcare use and mortality in patients with breathlessness, indicating pathways for tailored clinical care.

Key Points

  • To identify baseline clusters of multiple long-term conditions (MLTC) in adults presenting with new breathlessness and evaluate their links to subsequent healthcare utilization and mortality.
  • Conducted a retrospective cohort study using the Clinical Practice Research Datalink (CPRD) of adults with a first recorded code for breathlessness, analyzing patients with MLTCs (≥2 conditions; N=57,163) versus controls (≤1 condition; N=44,206).
  • Applied latent class analysis (LCA) to identify MLTC subgroup patterns and fitted regression models to evaluate two-year healthcare utilization and five-year mortality.
  • Latent class analysis identified 13 distinct MLTC classes among patients presenting with breathlessness.
  • The 'depression-prevalent with co-occurring anxiety and hypertension' class had the highest relative rate of primary care visits, while the 'hypertension-prevalent with co-occurring cerebrovascular disease' class had the highest rate of unplanned hospital admissions.
  • Five-year mortality risk peaked among patients in the 'learning disability-prevalent with co-occurring epilepsy' class compared to controls.

Cite This Study

Sathanapally et al. (2026) studied this question.

synapsesocial.com/papers/6a895eeeca7ade938187d22bhttps://doi.org/10.1038/s41598-026-66728-2
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Also Consider

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  1. 1Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts2024 · 14 citations
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  3. 3Rate and Timing of Long-Term Condition Accumulation Among Adults with Multiple Long-Term Conditions in England2026 · 1 citations
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  5. 5Primary healthcare utilisation among individuals with multimorbidity in deprived communities; a modelling study2026