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October 1, 2022BMJ OpenOpen Access

Early-onset burdensome multimorbidity: an exploratory analysis of sentinel conditions, condition accrual sequence and duration of three long-term conditions using the 1970 British Cohort Study

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Why the study?

Research on life course trajectories toward multimorbidity is limited and early-onset multimorbidity is poorly characterised.

Population

17 196 cohort members born in 1970

Design

Longitudinal birth cohort study

Follow-up

Age 46

Authors

SSSebastian StannardEHEmilia HollandSCSarah Crozier

Discussion

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Overview

May guide earlier prevention timing in deprived groups; leaves open causal validation and intervention trials.

Structured PICO

P
Population
17,196 cohort members born in 1970 from the 1970 British Cohort Study (BCS70)
O
Outcome
Prevalence of the most common three-condition multimorbidity group at age 46, nature and timing of sentinel conditions, sequencing patterns of subsequent LTC accrual, and permanency of psychological distress

Psychological distress and back pain are common sentinel conditions that, along with high blood pressure, form the most common three-condition multimorbidity group by midlife.

Cite This Study

Stannard et al. (2022) studied this question.

synapsesocial.com/papers/6a761a4a67b8a7e548707c9ahttps://doi.org/10.1136/bmjopen-2021-059587
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Also Consider

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  4. 4Rising to the challenge of multimorbidity2020 · 373 citations
  5. 5Six-year longitudinal course and outcomes of subtypes of depression2015 · 96 citations