What does this research mean for the field?

Increases in the inflammatory marker C-reactive protein (CRP) longitudinally predict poorer executive functioning and reduced response inhibition in young adults at risk for suicidal behavior. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the cross-sectional and longitudinal associations between stress-response biomarkers and neurocognitive functioning in young adults at risk for suicidal behavior.

August 22, 2026Translational PsychiatryOpen Access

The longitudinal association of stress-response biomarkers on neurocognitive functioning in young adults at-risk for suicidal behavior

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Authors

NTNermin ToukhyUniversity of Pittsburgh MJMeilin Jia-RichardsUniversity of Pittsburgh EGEli GoodfriendUniversity of Pittsburgh

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Implication

Prospective cohort study shows rising C-reactive protein predicts neurocognitive decline in young adults at risk for suicidal behavior, highlighting the role of systemic inflammation.

Key Points

To evaluate the cross-sectional and longitudinal associations between stress-response biomarkers and neurocognitive functioning in young adults at risk for suicidal behavior.
Assessed 254 participants aged 18–30 across four groups (66 with recent suicide attempts, 66 with suicidal ideation, 73 psychiatric controls, and 49 healthy controls) at baseline, 3, 6, and 12 months.
Measured hair cortisol, circulating inflammatory markers (CRP, IL-6, IL-10, IL-1ra, TNF-α), and neurocognitive domains, using inverse probability-weighted analysis to adjust for differential attrition across follow-up (43.1% retention).
Cross-sectionally, elevated CRP and IL-10 correlated with poorer executive functioning, though associations were not statistically significant after covariate adjustment.
Longitudinally, increases in CRP significantly predicted worsening executive functioning (β = 0.147, SE = 0.034, p < 0.001) and reduced response inhibition (β = 0.328, SE = 0.114, p = 0.004) after adjusting for covariates.

Cite This Study

Toukhy et al. (2026) studied this question.

synapsesocial.com/papers/6a895effca7ade938187d43f https://doi.org/10.1038/s41398-026-04365-z

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Implication

Prospective cohort study shows rising C-reactive protein predicts neurocognitive decline in young adults at risk for suicidal behavior, highlighting the role of systemic inflammation.

The longitudinal association of stress-response biomarkers on neurocognitive functioning in young adults at-risk for suicidal behavior

Discussion

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Implication

Key Points

Cite This Study

The longitudinal association of stress-response biomarkers on neurocognitive functioning in young adults at-risk for suicidal behavior

Discussion

Member takes

Implication

Key Points

Cite This Study

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