Why the study?
Does admission serum endocan level predict the presence of STEMI, coronary severity (SYNTAX score), and in-hospital mortality?
Does admission serum endocan level predict the presence of STEMI, coronary severity (SYNTAX score), and in-hospital mortality?
High admission serum endocan levels may serve as a useful biomarker for predicting the presence of STEMI, higher SYNTAX scores, and worse in-hospital cardiovascular outcomes.
Endocan may aid admission STEMI identification; leaves open incremental value over existing markers pending validation.
We assessed the prognostic role of serum endocan level in patients with ST-segment elevation myocardial infarction (STEMI) and compared the results with a normal coronary angiography group. A total of 133 patients were included in the study (88 patients with STEMI and 45 patients with normal coronary arteries). The SYNTAX score was determined based on the baseline coronary angiogram. Multivariate logistic regression analysis indicated that endocan independently correlated with the presence of STEMI. Moreover, high-sensitivity C-reactive protein (hsCRP), peak troponin I, and left ventricular ejection fraction (LVEF) were found to be independently associated with STEMI. Endocan level correlated significantly with hsCRP and SYNTAX score. We analyzed the discriminatory capability of endocan level for the presence of STEMI using a receiver-operating characteristics curve. A cutoff endocan level of 1.7 (ng/mL) predicted the presence of STEMI with a sensitivity of 76.1% and specificity of 73.6%. In conclusion, a high endocan level on hospital admission is an independent predictor of a worse cardiovascular outcome and a high SYNTAX score in patients with STEMI.
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Kundi et al. (2016) studied this question.
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