January 1, 1972Japanese Journal of Medical Science and BiologyOpen Access

Genetic Stability of Sabin Strain of Type 3 Poliovirus in the Sensitivity to Inhibitory Bovine Serum I. Selection of Inhibitory Bovine Serum Against Type 3 Sabin Strain and Sensitivity to the Serum of Vaccine Progenies

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Population

Type 3 Sabin vaccine strain, wild virus strains of the same type, and in vitro or human passage progenies of…

Comparison

Bovine inhibitory sera (BS-19 and BE-19) vs Wild virus strains of the same type

Design

Preclinical

Authors

TUTomoko UrasawaSapporo Medical University SUShozo UrasawaCenters for Disease Control and Prevention MKMasatsugu KanamitsuSapporo Medical University

Discussion

Member takes

Implication

Bovine sera may distinguish vaccine-derived from wild poliovirus; hypothesis-generating and requires validation before any diagnostic use.

Structured PICO

Population

Type 3 Sabin vaccine (Leon 12 a1b) strain, wild virus strains of the same type, and in vitro or human passage progenies of the vaccine virus; 495 bovine sera tested

Intervention

Bovine inhibitory sera (BS-19 and BE-19)

Comparator

Wild virus strains of the same type

Outcome

Sensitivity to inhibitory bovine serum (neutralization)surrogate

Bovine inhibitor markers may have practical utility for the identification of vaccine-derived polioviruses.

Cite This Study

Urasawa et al. (1972) studied this question.

synapsesocial.com/papers/6a895faaabb0ef83c5c97e75 https://doi.org/10.7883/yoken1952.25.169

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Implication

Bovine sera may distinguish vaccine-derived from wild poliovirus; hypothesis-generating and requires validation before any diagnostic use.

Genetic Stability of Sabin Strain of Type 3 Poliovirus in the Sensitivity to Inhibitory Bovine Serum I. Selection of Inhibitory Bovine Serum Against Type 3 Sabin Strain and Sensitivity to the Serum of Vaccine Progenies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic Stability of Sabin Strain of Type 3 Poliovirus in the Sensitivity to Inhibitory Bovine Serum I. Selection of Inhibitory Bovine Serum Against Type 3 Sabin Strain and Sensitivity to the Serum of Vaccine Progenies

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider