Population
Animals immunized with purified D-antigen or C-antigen of type 3 poliovirus; cells infected with poliovirus…
Comparison
Infection with Sabin type 3 vaccine strain virus vs Infection with strains genetically unrelated to…
Design
Preclinical
Authors
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Highlights strain-specific particle differences; leaves open implications for Sabin vaccine development and requires in vivo validation.
Sabin type 3 vaccine strain virus produces a distinct population of non-infectious 130S particles expressing C-antigen, unlike genetically unrelated strains.
Minor et al. (1980) studied this question.
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