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June 1, 1981Journal of General Virology

A Hybridoma Cell Line Secreting Antibody to Poliovirus Type 3 D-Antigen: Detection in Virus Harvest of Two D-Antigen Populations

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Population

Mouse hybridoma cell line obtained by fusion of a mouse myeloma cell line with spleen cells from mice…

Design

Preclinical

Authors

MFMichael A. J. FergusonBrigham and Women's HospitalGSG. C. SchildNational Institute for Biological Standards and ControlPMPhilip D. MinorUniversity of Essex

Discussion

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Implication

May inform type 3 poliovirus diagnostics; leaves open the 70S particle's role in infection or immunity.

Structured PICO

P
Population
Mouse hybridoma cell line (Mo56) obtained by fusion of a mouse myeloma cell line with spleen cells from mice immunized with Saukett virus
I
Intervention
Monoclonal antibody to poliovirus type 3 D-antigen
O
Outcome
Specificity and reactivity of the monoclonal antibody in virus-neutralization, single-radial-diffusion, and immunoprecipitation testssurrogate

The study describes a novel monoclonal antibody specific for poliovirus type 3 D-antigen that identifies a previously undescribed 70S poliovirus particle.

Cite This Study

Ferguson et al. (1981) studied this question.

synapsesocial.com/papers/6a9079bafdaee66aea840f6ehttps://doi.org/10.1099/0022-1317-54-2-437
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigenic Characterization of Poliovirus Type 3 Using Monoclonal Antibodies1984 · 5 citations
  2. 2The Preparation of Specific Immune Sera against Type 3 Poliovirus D-Antigen and C-Antigen and the Demonstration of Two C-Antigenic Components in Vaccine Strain Populations1980 · 30 citations
  3. 3Monoclonal Antibodies to Polioviruses1981 · 65 citations
  4. 4Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies1982 · 137 citations
  5. 5Neutralization Epitopes on Poliovirus Type 3 Particles: an Analysis Using Monoclonal Antibodies1984 · 49 citations