Population
Murine lymphocyte hybridomas
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May aid poliovirus strain surveillance; leaves open human clinical translation from this animal model.
Structured PICO
P
Population
Murine lymphocyte hybridomas
I
Intervention
Generation of monoclonal antibodies to polioviruses
O
Outcome
Production of neutralizing or non-neutralizing monoclonal antibodies to type 1, 2 or 3 poliovirus strains
The study successfully isolated murine hybridomas producing monoclonal antibodies specific to the three Sabin poliovirus vaccine strains.
Cite This Study
Osterhaus et al. (1981) studied this question.