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May 1, 1988Proceedings of the National Academy of SciencesOpen Access

Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.

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Why the study?

Does injection of a PV-1/PV-3 hybrid virus elicit neutralizing antibodies against both serotypes in rabbits and monkeys?

Population

Rabbits and monkeys (primates)

Design

Preclinical

Authors

MMMichael G. MurraySouthern Research InstituteRKRichard KühnBavarian Academy of Sciences and HumanitiesMAMinetaro AritaNational Institute of Infectious Diseases

Discussion

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Implication

Animal data support hybrid antigens for multivalent picornavirus vaccines; leaves open human translation and safety.

Structured PICO

Does injection of a PV-1/PV-3 hybrid virus elicit neutralizing antibodies against both serotypes in rabbits and monkeys?

P
Population
Rabbits and monkeys (primates)
I
Intervention
Injection of a hybrid poliovirus in which N-AgI of PV-1 was replaced by N-AgI of PV-3
O
Outcome
Production of antisera that neutralize both PV-1 and PV-3surrogate

Sequence replacement at N-AgI of poliovirus is compatible with viral proliferation and elicits multivalent neutralizing antibodies, which may be useful for the development of multivalent picornavirus vaccines.

Cite This Study

Murray et al. (1988) studied this question.

synapsesocial.com/papers/6a85232fff13e6e4e743d2dfhttps://doi.org/10.1073/pnas.85.9.3203
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Also Consider

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  1. 1Principal and Subsidiary Antigenic Sites of VP1 Involved in the Neutralization of Poliovirus Type 31985 · 78 citations
  2. 2Antigenic Variation and Resistance to Neutralization in Poliovirus Type 11985 · 126 citations
  3. 3Functional basis of poliovirus neutralization determined with monospecific neutralizing antibodies1983 · 104 citations
  4. 4Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants.1988 · 44 citations
  5. 5Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome.1981 · 555 citations