Antigenic structure of chimeras of type 1 and type 3 poliovirus involving antigenic site 1

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Population

Chimeric polioviruses (Sabin strain of type 1 and type 3) and animal models for immunogenicity

Design

Preclinical

Authors

Discussion

Chimeric polioviruses may induce strain-specific antibodies in animals; leaves open translation to human vaccines.

Population

Chimeric polioviruses (Sabin strain of type 1 and type 3) and animal models for immunogenicity

Intervention

Chimeric polioviruses with part of antigenic site 1-encoding sequence of Sabin type 1 replaced by Sabin type 3 sequences

Outcome

Reaction with polyclonal and monoclonal antibodies, and immunogenicity in animalssurrogate

Chimeric polioviruses can induce strain-specific antibodies, with immunogenicity paralleling their antigenic reactivity.

Minor et al. (1990) studied this question.

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