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June 1, 1991Journal of VirologyOpen Access

Chimeric polioviruses that include sequences derived from two independent antigenic sites of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies against FMDV in guinea pigs

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Population

Guinea pigs

Design

Preclinical

Authors

JKJ. D. A. KitsonFox Chase Cancer CenterKBKaren L. BurkeThe Pirbright InstituteLPL. A. Pullen

Discussion

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Implication

Guinea pig data support advancing chimeric FMDV vaccines; leaves open validation in livestock and humans.

Structured PICO

P
Population
Guinea pigs
I
Intervention
Chimeric polioviruses (O1.3 and O3.1) containing foot-and-mouth disease virus (FMDV) antigenic sites
O
Outcome
Induction of site-specific FMDV-neutralizing antibodies and protective response against FMDV challengesurrogate

Chimeric polioviruses expressing FMDV antigenic sites can induce neutralizing antibodies and provide partial protection against FMDV challenge in a guinea pig model.

Cite This Study

Kitson et al. (1991) studied this question.

synapsesocial.com/papers/6a7065cfac440176ef29105fhttps://doi.org/10.1128/jvi.65.6.3068-3075.1991
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neutralizing Epitopes of Type O Foot-and-Mouth Disease Virus. II. Mapping Three Conformational Sites with Synthetic Peptide Reagents1989 · 91 citations
  2. 2Serological Prospects for Peptide Vaccines against Foot-and-Mouth Disease Virus1989 · 36 citations
  3. 3Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II1989 · 40 citations
  4. 4Antigenic Structure of Polioviruses of Serotypes 1, 2 and 31986 · 309 citations
  5. 5Antigenicity and Immunogenicity of Synthetic Peptides of Foot-and-Mouth Disease Virus1987 · 59 citations