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October 1, 1991Journal of General Virology

Antigenic structure of chimeras of type 1 and type 3 polioviruses involving antigenic sites 2, 3 and 4

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Population

Chimeric polioviruses

Design

Preclinical

Authors

PMPhilip D. MinorUniversity of EssexMFMichael A. J. FergusonBrigham and Women's HospitalKKKersi KatrakNational Institute for Biological Standards and Control

Discussion

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Implication

May inform poliovirus chimera design; leaves open whether epitope transfer translates to human vaccines or immunity.

Structured PICO

P
Population
Chimeric polioviruses (type 1 Sabin strain with regions corresponding to antigenic sites 2, 3, and 4 replaced by type 3 Sabin strain)
I
Intervention
Replacement of antigenic sites 2, 3, and 4
O
Outcome
Expression of antigenic properties of type 3 (assessed by reaction with polyclonal or monoclonal antibodies, or by immunogenicity)

Continuous sequence antigenic sites are more readily transferred between poliovirus types in chimeras compared to complex conformational sites.

Cite This Study

Minor et al. (1991) studied this question.

synapsesocial.com/papers/6a8525a676469a949f43d27dhttps://doi.org/10.1099/0022-1317-72-10-2475
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigenic Structure of Polioviruses of Serotypes 1, 2 and 31986 · 309 citations
  2. 2Three-dimensional structure of poliovirus serotype 1 neutralizing determinants1988 · 222 citations
  3. 3Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II1989 · 40 citations
  4. 4Differences in conformation of type 3 poliovirus antigenic sites on non-infectious empty particles and infectious virus1990 · 12 citations
  5. 5Principal and Subsidiary Antigenic Sites of VP1 Involved in the Neutralization of Poliovirus Type 31985 · 78 citations