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December 1, 1989Journal of VirologyOpen Access

Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II

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Population

Poliovirus type 1 (Mahoney) and rabbits inoculated with the hybrid virus

Design

Preclinical

Authors

AMAndrew D. MurdinSanofi (Canada)EWEckard WimmerCalifornia Institute of Technology

Discussion

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Implication

May guide multivalent poliovirus vaccine development; leaves open human safety and efficacy.

Structured PICO

P
Population
Poliovirus type 1 (Mahoney) and rabbits inoculated with the hybrid virus
I
Intervention
Replacement of a part of N-AgII (amino acids 158 to 173 of VP2) of PV-1(Mahoney) with the equivalent sequence from PV-2(Lansing)
O
Outcome
Viability of the hybrid virus and induction of neutralizing antibodies against both PV-1 and PV-2 in rabbitssurrogate

Manipulation of the N-AgII antigenic site is a viable method for producing hybrid polioviruses that induce neutralizing antibodies against multiple serotypes.

Cite This Study

Murdin et al. (1989) studied this question.

synapsesocial.com/papers/6a845eb0c0e58a00207bf8a9https://doi.org/10.1128/jvi.63.12.5251-5257.1989
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.1988 · 91 citations
  2. 2Identification of a new neutralization antigenic site on poliovirus coat protein VP21984 · 42 citations
  3. 3Poliovirus Host Range Is Determined by a Short Amino Acid Sequence in Neutralization Antigenic Site I1988 · 161 citations
  4. 4Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.1982 · 310 citations
  5. 5Mapping of sequences required for mouse neurovirulence of poliovirus type 2 Lansing1986 · 198 citations