Key result
An inhibitory factor in bovine serum selectively neutralized the CHAT type 1 attenuated poliovirus in a cell-free system according to first order kinetics, with reactivation occurring at pH below 5.0.
Population
Poliovirus strains
Design
Preclinical
Authors
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Does not alter polio vaccination or therapy; leaves open the in vivo role of selective serum factors in viral neutralization.
Bovine serum contains a highly selective 19 S globulin factor capable of neutralizing specific strains of poliovirus in vitro.
Pagano et al. (1965) studied Poliovirus. Inhibitory bovine serum was evaluated on Plaque formation and cell-free neutralization. An inhibitory factor in bovine serum selectively neutralized the CHAT type 1 attenuated poliovirus in a cell-free system according to first order kinetics, with reactivation occurring at pH below 5.0.
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