Key result
Sera of cows and steers possessed high titers of specific neutralizing antibodies against poliomyelitis viruses, whereas sera of dogs, cats, calves, and lambs possessed no neutralizing activity.
Observational
Variable neutralizing activity across species cautions against uniform animal model assumptions; leaves open seroprevalence studies in veterinary populations.
(1) The sera of cows and steers were shown to possess neutralizing substances in high titer against the viruses of poliomyelitis. These have been shown to be specific antibodies against the viruses of poliomyelitis. (2) The sera of horses, hogs and chickens also possessed modest neutralizing activity against the viruses of poliomyelitis. (3) The sera of dogs, cats, calves and lambs do not possess neutralizing activity against the viruses of poliomyelitis. (4) Attempts to isolate a virus from the bovine species that might explain the origin of these antibodies were unsuccessful. The antigenic stimulus giving rise to antibodies against the viruses of poliomyelitis remains unknown.
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Bartell et al. (1955) conducted an observational in Poliomyelitis. Sera of domestic animals was evaluated on Presence of neutralizing antibodies against poliomyelitis viruses. Sera of cows and steers possessed high titers of specific neutralizing antibodies against poliomyelitis viruses, whereas sera of dogs, cats, calves, and lambs possessed no neutralizing activity.
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