The study highlights that the production of neutralizing antibodies against poliomyelitis virus can be significantly delayed following infection or inoculation.
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Delayed antibody detection may miss recent poliomyelitis; leaves open optimal serologic timing and protective immunity assessment.
It is difficult to understand why neutralizing antibodies against poliomyelitis virus are not always found in the serums of patients immediately after they recover from the acute stage of the disease. In a few instances in my experience they did not appear until a long time after recovery. There has been some parallel experimental evidence in animals, for it has been found that when a horse is inoculated with poliomyelitis virus some time may elapse before antibodies appear. With 2 horses it was found that the first specimens of blood, taken within a few weeks after the end of a series of injections of virus, not only failed to neutralize the virus but actually caused an accelerated production of the disease in Macaca mulatta monkeys. The poliomyelitis antiserum obtained from 1 horse described previously1contained potent antibodies which could neutralize not only homologous (Flexner's M. V.) but several heterologous
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John A. Toomey (1943) studied this question.
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