Key result
Repeated injections of poliomyelitis virus in refractory animals generally produced poor antiserum responses, though one horse produced highly potent immune serum neutralizing at least 25,000 doses.
Why the study?
Does repeated injection of poliomyelitis virus induce immune serum production in refractory animals?
Does repeated injection of poliomyelitis virus induce immune serum production in refractory animals?
While most poliomyelitis refractory animals respond poorly to virus injections, individual animals such as horses can produce highly potent immune serum.
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Variable responses among refractory animals limit reliable antiserum production; leaves open selective identification of high-responder individuals for potent serum.
Schultz et al. (1934) studied Poliomyelitis (n=12). Poliomyelitis virus injections was evaluated on Serological responsiveness (virucidal tests). Repeated injections of poliomyelitis virus in refractory animals generally produced poor antiserum responses, though one horse produced highly potent immune serum neutralizing at least 25,000 doses.
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