Population
L cells infected with reovirus
Comparison
Cycloheximide at a concentration of 10 mug/ml… vs Infected culture without the drug
Design
Preclinical
Authors
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Preclinical data warrant caution against clinical extrapolation; leaves open whether labile proteins drive dsRNA synthesis across viruses or hosts.
Cycloheximide selectively inhibits double-stranded reovirus RNA synthesis when added late in infection, suggesting that double-stranded RNA synthesis requires prior synthesis of a new protein with rapid turnover.
Watanabe et al. (1967) studied this question.
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