Why the study?
Do Class I and Class III antiarrhythmic agents alter refractory period extension by transcardiac shocks in anesthetized dogs?
Population
Pentobarbital anesthetized dogs (n=26 total: flecainide n=7, encainide n=7, clofilium n=7, vehicle n=5)
Comparison
Class I agents flecainide or encainide, or the… vs Vehicle
Design
Preclinical
Authors
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Class III agents may enhance shock-induced refractory period extension in dogs; leaves open translation to human defibrillation thresholds.
Do Class I and Class III antiarrhythmic agents alter refractory period extension by transcardiac shocks in anesthetized dogs?
Class III antiarrhythmic agents significantly increase refractory period extension by transcardiac shocks, which may help explain their influence on defibrillation thresholds.
Sweeney et al. (1996) studied this question.
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