Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model.
Why the study?
Does oral clofilium reduce defibrillation energy requirements in a canine model?
Population
12 dogs with implanted epicardial patch electrodes
Comparison
Oral clofilium 100 mg/day for 3 weeks vs Control dogs undergoing repeated testing without…
Design
Preclinical
Follow-up
28 days
Authors
Discussion
Loading...
Member takes
Implication
May inform antiarrhythmic development for defibrillation thresholds; leaves open translation from canine models to humans.
Structured PICO
Does oral clofilium reduce defibrillation energy requirements in a canine model?
P
Population
12 dogs with implanted epicardial patch electrodes
I
Intervention
Oral clofilium 100 mg/day for 3 weeks
C
Comparator
Control dogs (n=6) undergoing repeated testing without clofilium
O
Outcome
Energy and current for 50% success in defibrillation (E50 and I50)surrogate
Oral clofilium produces a sustained reduction in defibrillation energy and current requirements in a canine model.
Cite This Study
Dorian et al. (1991) studied this question.