Why the study?
Does clofilium infusion alter electrophysiologic parameters and prevent inducible arrhythmias in patients with a history of arrhythmias?
Population
25 patients (22 with a history of ventricular arrhythmias and 3 with paroxysmal supraventricular arrhythmias)
Design
Case_series
Follow-up
up to 2 weeks
Authors
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Hypothesis-generating in case reports; leaves open clofilium's role in arrhythmia management pending controlled trials.
Does clofilium infusion alter electrophysiologic parameters and prevent inducible arrhythmias in patients with a history of arrhythmias?
Clofilium safely increases atrial and ventricular effective refractory periods and demonstrates potential in preventing inducible ventricular tachycardia.
Platia et al. (1984) studied this question.
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