What question did this study set out to answer?

July 1, 1981Journal of Cardiovascular PharmacologyOpen Access

Cellular Electrophysiology of Clofilium, a New Antifibrillatory Agent, in Normal and Ischemic Canine Purkinje Fibers

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Why the study?

Does clofilium alter action potential duration and refractoriness in normal and ischemic canine Purkinje fibers?

Population

Isolated canine cardiac tissues from normal dogs and dogs subjected to occlusion of the left anterior…

Design

Preclinical

Authors

MSMitchell I. SteinbergBeiersdorf (Germany)MSMark SullivanOxford University Hospitals NHS Trust SWSally A. WiestEli Lilly (United States)

Discussion

Member takes

Implication

May support preclinical testing of clofilium for ischemic arrhythmia models; leaves open translation to clinical use.

Key Points

This research aims to investigate the effects of clofilium on action potential duration and refractoriness in canine Purkinje fibers under normal and ischemic conditions.
Electrophysiological studies on isolated canine cardiac Purkinje fibers.
Use of clofilium at concentrations of 3 X 10(-8) to 3 X 10(-7) M.
Comparison of action potential duration in normal and ischemic zones following coronary artery occlusion.
Clofilium increased action potential duration in both normal and ischemic zones, with a more pronounced effect in normal areas.
Clofilium enhanced the effective refractory period in normal areas more than in the ischemic zone.
No significant changes in the rate of rise of action potentials (Vmax) or conduction observed.

Structured PICO

Does clofilium alter action potential duration and refractoriness in normal and ischemic canine Purkinje fibers?

Population

Isolated canine cardiac tissues (Purkinje fibers) from normal dogs and dogs subjected to occlusion of the left anterior descending coronary artery 48 hr before study

Intervention

Clofilium (3 X 10(-8)--10(-6) M)

Outcome

Action potential duration (APD) and refractorinesssurrogate

Clofilium increases action potential duration and refractoriness in both normal and ischemic canine Purkinje fibers, reducing APD disparity between zones without altering conduction velocity, which may underlie its antifibrillatory effects.

Cite This Study

Steinberg et al. (1981) studied this question.

synapsesocial.com/papers/6a20799014cb6ef00ff48d55 https://doi.org/10.1097/00005344-198107000-00022

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Cellular Electrophysiology of Clofilium, a New Antifibrillatory Agent, in Normal and Ischemic Canine Purkinje Fibers

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cellular Electrophysiology of Clofilium, a New Antifibrillatory Agent, in Normal and Ischemic Canine Purkinje Fibers

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider