What question did this study set out to answer?

The aim is to assess whether clofilium has antifibrillatory activity in a model of ventricular fibrillation induced by pinacidil and hypoxia.

September 1, 1994British Journal of PharmacologyOpen Access

Antifibrillatory effects of clofilium in the rabbit isolated heart

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Why the study?

Does clofilium prevent ventricular fibrillation in a rabbit isolated heart model?

Population

Rabbit isolated hearts subjected to a pinacidil + hypoxia-induced model of ventricular fibrillation or…

Comparison

Clofilium or bolus administration vs Vehicle

Design

Preclinical

Authors

GFGregory S. FriedrichsNovartis (Switzerland)LCLiguo ChiUniversity of California, San Diego AGAlysia L. GreenUniversity of Michigan

Discussion

Member takes

Implication

Cautions against clinical use of clofilium for VF; leaves open whether KATP blockade prevents arrhythmias beyond this rabbit model.

Key Points

The aim is to assess whether clofilium has antifibrillatory activity in a model of ventricular fibrillation induced by pinacidil and hypoxia.
Using Langendorff-perfused rabbit hearts, clofilium was administered at concentrations of 0.1, 1.0, and 10.0 microM.
Hearts were exposed to pinacidil and subjected to 12 minutes of hypoxia followed by reoxygenation, recording VF onset.
Additional treatments included UK-68,798 and 5-hydroxydecanoate to evaluate their impact on VF incidence.
Clofilium reduced the incidence of VF from 7/9 in control hearts to 1/9 at 10.0 microM (P = 0.007).
In separate trials, clofilium converted electrically-induced VF to sinus rhythm in 10/11 hearts.
5-hydroxydecanoate showed protective effects against VF, whereas UK-68,798 did not.

Structured PICO

Does clofilium prevent ventricular fibrillation in a rabbit isolated heart model?

Population

Rabbit isolated hearts (Langendorff-perfused) subjected to a pinacidil + hypoxia-induced model of ventricular fibrillation (VF) or electrically-induced VF

Intervention

Clofilium (0.1, 1.0, and 10.0 microM) or bolus administration

Comparator

Vehicle

Outcome

Incidence of ventricular fibrillation (VF)surrogate

Clofilium demonstrates concentration-dependent antifibrillatory effects in a rabbit isolated heart model, likely involving blockade of KATP channels.

Cite This Study

Friedrichs et al. (1994) studied this question.

synapsesocial.com/papers/6a70e35c5d37378ac1de0daf https://doi.org/10.1111/j.1476-5381.1994.tb16195.x

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Antifibrillatory effects of clofilium in the rabbit isolated heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Antifibrillatory effects of clofilium in the rabbit isolated heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider