Why the study?
Does clofilium affect transient outward K+ currents in Xenopus oocytes expressing cloned cardiac K+ channels?
Population
Xenopus oocytes expressing a cloned Ito-type cardiac K+ channel (RHK1)
Comparison
Extracellular application of clofilium vs Control (baseline/no drug)
Design
Preclinical
Authors
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May aid studies of K+ channel inactivation; leaves open translation to mammalian or clinical contexts.
Does clofilium affect transient outward K+ currents in Xenopus oocytes expressing cloned cardiac K+ channels?
Clofilium unexpectedly enhances transient outward K+ currents by shifting the inactivation curve, suggesting it may be a useful pharmacological tool for studying channel inactivation.
Kobayashi et al. (1995) studied this question.
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