Population
Cloned K+ channels, specifically human ether-a-go-go related gene channels, HERG S631A and S620T mutant…
Design
Preclinical
Authors
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Does not support clinical use; leaves open whether HERG potency predicts antiarrhythmic efficacy in humans.
Clofilium and its analog LY97241 exert their antiarrhythmic effects through potent and specific blockade of HERG channels, with LY97241 binding being affected by channel inactivation.
Suessbrich et al. (1997) studied this question.
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