Why the study?
Does clofilium affect multiple membrane currents in guinea pig ventricular myocytes?
Population
Cardiac myocytes isolated from guinea pig ventricle
Design
Preclinical
Authors
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Clofilium's multi-current effects remain hypothesis-generating in myocytes; does not support clinical use or practice change.
Does clofilium affect multiple membrane currents in guinea pig ventricular myocytes?
Clofilium affects both inward and outward currents in mammalian cardiac myocytes, suggesting its antiarrhythmic action involves multiple membrane currents beyond just class-III K+ channel blockade.
Li et al. (1996) studied this question.
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