February 1, 1992British Journal of PharmacologyOpen Access

Blockade of delayed rectifier K+ currents in neuroblastoma × glioma hybrid (NG 108–15) cells by clofilium, a class III antidysrhythmic agent

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Population

Undifferentiated mouse neuroblastoma x rat glioma hybrid (NG 108-15) cells

Comparison

Clofilium (0.3 to 70 microM) bath application vs Control conditions and sotalol (100 or 300 microM)

Design

Preclinical

Authors

HRHelen L. ReeveCounty Durham and Darlington NHS Foundation Trust CPChris PeersElectrophysiology

Discussion

Member takes

Implication

Clofilium's irreversible IKv block may guide selective channel studies; leaves open sotalol mechanisms in intact myocardium.

Structured PICO

Population

Undifferentiated mouse neuroblastoma x rat glioma hybrid (NG 108-15) cells

Intervention

Clofilium (0.3 to 70 microM) bath application

Comparator

Control conditions and sotalol (100 or 300 microM)

Outcome

Inhibition of voltage-activated delayed rectifier K+ currents (IKv)surrogate

Clofilium, but not sotalol, irreversibly and dose-dependently blocks delayed rectifier K+ currents in NG 108-15 cells in a voltage- and use-dependent manner.

Cite This Study

Reeve et al. (1992) studied this question.

synapsesocial.com/papers/6a7e06bf8b7e38892f15171b https://doi.org/10.1111/j.1476-5381.1992.tb14275.x

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Blockade of delayed rectifier K+ currents in neuroblastoma × glioma hybrid (NG 108–15) cells by clofilium, a class III antidysrhythmic agent

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Blockade of delayed rectifier K+ currents in neuroblastoma × glioma hybrid (NG 108–15) cells by clofilium, a class III antidysrhythmic agent

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider