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July 1, 1968Cardiovascular Research

Effect of the Pericardium on Left Ventricular Volume and Function in Acute Hypervolaemia

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Why the study?

Does pericardiectomy affect left ventricular volume and function during acute hypervolaemia in dogs?

Population

20 dogs subjected to acute volume overload

Comparison

Pericardiectomy (n=9) vs Intact pericardium (n=11)

Design

Preclinical

Authors

SBStuart H. BartleCharlottesville Medical ResearchHHHector J. HermannUniversity of VirginiaJCJ. W. CavoUniversity of Virginia Medical Center

Discussion

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Implication

Pericardium may constrain LV dilatation in acute overload; animal data leaves open human relevance.

Structured PICO

Does pericardiectomy affect left ventricular volume and function during acute hypervolaemia in dogs?

P
Population
20 dogs subjected to acute volume overload
I
Intervention
Pericardiectomy (n=9)
C
Comparator
Intact pericardium (n=11)
O
Outcome
End-diastolic and end-systolic left ventricular volumes and ejection fraction determined by biplane angiocardiographysurrogate

The pericardium plays a crucial role in preventing excessive left ventricular dilatation and functional impairment during acute volume overload.

Cite This Study

Bartle et al. (1968) studied this question.

synapsesocial.com/papers/6a89641eb4e829b19bd44596https://doi.org/10.1093/cvr/2.3.284

Topics

Mitral valve intervention
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of pericardium on the end-systolic pressure-segment length relationship in canine left ventricle in acute volume overload.1983 · 19 citations
  2. 2Pericardial influences on right and left ventricular filling dynamics.1991 · 38 citations
  3. 3Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs.1981 · 64 citations
  4. 4Influence of the pericardium on right and left ventricular filling in the dog1987 · 47 citations
  5. 5Pericardium modulates left and right ventricular stroke volumes to compensate for sudden changes in atrial volume2003 · 79 citations