November 24, 2005Arteriosclerosis Thrombosis and Vascular Biology
The Apolipoprotein B/AI Ratio and the Metabolic Syndrome Independently Predict Risk for Myocardial Infarction in Middle-Aged Men
Key result
An apolipoprotein B/AI ratio ≥0.9 (HR 1.48; 95% CI 1.15-1.91) and the metabolic syndrome (HR 1.69; 95% CI 1.30-2.21) independently predicted long-term risk of myocardial infarction in men.
Why the study?
Do an elevated apoB/AI ratio and the metabolic syndrome independently predict the risk of myocardial infarction in middle-aged men?
Population
1826 men aged 50 at baseline, community-based sample
Comparison
ApoB/AI ratio ≥0.9 and presence of metabolic… vs ApoB/AI ratio <0.9 and absence of metabolic…
Design
Cohort
Follow-up
median 26.8 years
Authors
Discussion
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Implication
May refine MI risk stratification in middle-aged men; extends observational data but leaves open need for prospective validation.
Study Design
Type
Cohort (n=1,826)
Structured PICO
Do an elevated apoB/AI ratio and the metabolic syndrome independently predict the risk of myocardial infarction in middle-aged men?
P
Population
1,826 men aged 50 from a community-based sample, followed for a median of 26.8 years to assess the incidence of myocardial infarction.
E
Exposure
ApoB/AI ratio ≥0.9 and presence of metabolic syndrome (National Cholesterol Education Program definition)
C
Comparator
ApoB/AI ratio <0.9 and absence of metabolic syndrome
O
Outcome
Incidence of fatal and nonfatal myocardial infarctionhard clinical
Main Result
Hazard Ratio: 1.48 (95% CI 1.15–1.91)
Both an elevated apoB/AI ratio and the metabolic syndrome are independent long-term predictors of myocardial infarction in middle-aged men.
Cite This Study
Lind et al. (2005) conducted a cohort in Myocardial Infarction (n=1,826). Apolipoprotein B/AI ratio ≥0.9 and metabolic syndrome vs. Apolipoprotein B/AI ratio <0.9 and absence of metabolic syndrome was evaluated on Fatal and nonfatal myocardial infarction (HR 1.48, 95% CI 1.15-1.91). An apolipoprotein B/AI ratio ≥0.9 (HR 1.48; 95% CI 1.15-1.91) and the metabolic syndrome (HR 1.69; 95% CI 1.30-2.21) independently predicted long-term risk of myocardial infarction in men.