Key result
The DASH dietary pattern significantly reduced systolic blood pressure by 9.60 mmHg at two weeks in unmedicated hypertensive adults (P=0.039).
Why the study?
Does the DASH dietary pattern reduce blood pressure and improve vascular biomarkers in unmedicated hypertensive adults?
RCT (n=20)
randomized
Does the DASH dietary pattern reduce blood pressure and improve vascular biomarkers in unmedicated hypertensive adults?
p-value: p=0.039
The DASH diet significantly lowers blood pressure in unmedicated hypertensive adults, with effects potentially mediated by improved nitric oxide bioavailability and early natriuresis.
Supports DASH diet as initial nonpharmacologic therapy in unmedicated hypertension; confirms short-term efficacy and extends vascular biomarker evidence.
Potential blood pressure- (BP-) lowering mechanisms of the DASH dietary pattern were measured in 20 unmedicated hypertensive adults in a controlled feeding study. At screening, participants averaged 44.3 ± 7.8 years, BMI 33.9 ± 6.6 Kg/m(2), and BP 144.2 ± 9.38/88.5 ± 6.03 mmHg. All consumed a control diet for one week, then were randomized to control or DASH for another two weeks (week one and two). With DASH, but not controls, SBP fell by 10.65 ± 12.89 (P = 0.023) and 9.60 ± 11.23 (P = 0.039) mmHg and DBP by 5.95 ± 8.01 (P = 0.069) and 8.60 ± 9.13 mmHg (P = 0.011) at the end of week one and two, respectively. Univariate regressions showed that changes in urinary sodium/potassium ratio (β = 1.99) and plasma renin activity (β = -15.78) and percent change in plasma nitrite after hyperemia were associated with SBP changes at week one (all P < 0.05). Plasma nitrite following hyperemia showed a treatment effect (P = 0.014) and increased at week two (P = 0.001). Pulse wave velocity decreased over time with DASH (trend P = 0.019), and reached significance at week two (P = 0.026). This response may be mediated by an improvement in upregulation of nitric oxide bioavailability. Early natriuresis and reductions in oxidative stress cannot be ruled out. Future studies are needed to verify these findings, assess the possibility of earlier effects, and examine other potential mediators.
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Lin et al. (2012) conducted an RCT in hypertension (n=20). DASH dietary pattern vs. control diet was evaluated on Change in systolic blood pressure at week two (p=0.039). The DASH dietary pattern significantly reduced systolic blood pressure by 9.60 mmHg at two weeks in unmedicated hypertensive adults (P=0.039).
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