Key result
A high-fat/high-calorie diet for 12 weeks in juvenile pigs induced early obesity, increased vascular oxidative stress, and reduced coronary endothelium-dependent vasorelaxation.
Why the study?
Does a high-fat/high-calorie diet induce coronary endothelial dysfunction and oxidative stress in juvenile domestic crossbred pigs?
Population
juvenile domestic crossbred pigs
Comparison
high-fat/high-calorie diet (HF) for 12 weeks vs normal chow diet
Design
Preclinical, randomized
Follow-up
12 wk
Authors
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Early obesity may impair coronary endothelial function before insulin resistance; hypothesis-generating in juvenile models and requires human confirmation.
RCT
randomized
Does a high-fat/high-calorie diet induce coronary endothelial dysfunction and oxidative stress in juvenile domestic crossbred pigs?
Early obesity causes coronary endothelial dysfunction and local vascular oxidative stress before the onset of insulin resistance.
Galili et al. (2006) conducted an RCT in Obesity. High-fat/high-calorie diet vs. Normal chow diet was evaluated on Coronary endothelial function and oxidative stress. A high-fat/high-calorie diet for 12 weeks in juvenile pigs induced early obesity, increased vascular oxidative stress, and reduced coronary endothelium-dependent vasorelaxation.
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