What question did this study set out to answer?

To evaluate whether intravenous radioiodinated fatty acid bound to albumin can selectively label cardiac muscle and detect myocardial infarction on thoracic photoscans.

January 1, 1965Circulation ResearchOpen Access

Use of Radioiodinated Fatty Acid for Photoscans of the Heart

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Why the study?

Can intravenous injection of radioiodinated fatty acid bound to albumin (RIFA) detect areas of myocardial infarction on photoscans?

Population

Dogs (including 14 with one coronary artery ligated) and 3 moribund human subjects with myocardial infarction

Comparison

Intravenous injection of radioiodinated fatty… vs Intravenous injection of radioiodinated serum…

Design

Preclinical

Authors

JEJohn R. EvansSwinburne University of Technology RGR. W. GuntonWestern University RBR. BakerOntario Institute for Cancer Research

Discussion

Member takes

Implication

Initial data support RIFA photoscanning for MI detection in dogs and few humans; leaves open clinical translation pending validation.

Key Points

To evaluate whether intravenous radioiodinated fatty acid bound to albumin can selectively label cardiac muscle and detect myocardial infarction on thoracic photoscans.
Administered intravenous radioiodinated fatty acid bound to albumin (RIFA), radioiodinated serum albumin, or sodium iodide-131 to canine models, including 14 dogs with experimental coronary artery ligation.
Conducted thoracic photoscans and postmortem tissue radioactivity analyses in dogs and three moribund human subjects who received RIFA shortly before death.
Thoracic photoscans identified distinct myocardial infarction defect areas in 11 of 14 dogs subjected to coronary artery ligation.
Postmortem tissue examination revealed substantially higher radioactivity concentrations in healthy myocardium compared to infarcted tissue in both canine models and all three human subjects.

Structured PICO

Can intravenous injection of radioiodinated fatty acid bound to albumin (RIFA) detect areas of myocardial infarction on photoscans?

Population

Dogs (including 14 with one coronary artery ligated) and 3 moribund human subjects with myocardial infarction

Intervention

Intravenous injection of radioiodinated fatty acid bound to albumin (RIFA)

Comparator

Intravenous injection of radioiodinated serum albumin or NaI 131

Outcome

Detection of myocardial infarction via photoscans of the thoraxsurrogate

Radioiodinated fatty acid bound to albumin (RIFA) can be used to visualize healthy myocardium and detect areas of myocardial infarction via photoscans.

Cite This Study

Evans et al. (1965) studied this question.

synapsesocial.com/papers/6a896a5d5c716ca1a5d443cb https://doi.org/10.1161/01.res.16.1.1

Topics

Sermorelin

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