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March 1, 1976Diabetes

Growth of Rabbit Aortic Smooth-Muscle Cells Cultured in Media Containing Diabetic and Hyperlipemic Serum

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Why the study?

Does diabetic serum stimulate the growth of rabbit aortic smooth-muscle cells compared to normal serum?

Population

Smooth-muscle cell cultures grown from thoracic aortas of normal and diabetic rabbits

Comparison

Media containing diabetic rabbit serum or… vs Media containing normal serum with or without…

Design

Preclinical

Authors

TLThomas LedetSanford Burnham Prebys Medical Discovery InstituteKDK. DzogaArgonne National LaboratoryRWR. W. WisslerOregon Health & Science University

Discussion

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Implication

Diabetic serum may promote vascular smooth-muscle proliferation via an unidentified factor; hypothesis-generating for diabetic macroangiopathy mechanisms.

Structured PICO

Does diabetic serum stimulate the growth of rabbit aortic smooth-muscle cells compared to normal serum?

P
Population
Smooth-muscle cell cultures grown from thoracic aortas of normal and diabetic rabbits
I
Intervention
Media containing diabetic rabbit serum or hyperlipemic serum from nondiabetic rabbits
C
Comparator
Media containing normal serum with or without added glucose
O
Outcome
Cell growth in rapid-growth and stationary phasessurrogate

Diabetic serum contains a non-glucose, non-insulin, non-lipid factor that stimulates excessive growth of arterial medial cells, which may be relevant to understanding human diabetic macroangiopathy.

Cite This Study

Ledet et al. (1976) studied this question.

synapsesocial.com/papers/6a896b8dab60fc7a26719d55https://doi.org/10.2337/diab.25.3.207
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Significance of Phenotypic Changes of Aortic Smooth Muscle Cells in the Intimal Thickening of Diabetic Artery1993
  2. 2Diabetes mellitus induces accelerated growth of aortic smooth muscle cells: association with overexpression of PDGF <i>β</i>‐receptors1993 · 72 citations
  3. 3Proliferative Effect of Insulin on Cultured Smooth Muscle Cells From Rat Mesenteric Resistance Vessels1998 · 39 citations
  4. 4Atherosclerosis and myocardial ischemic lesions in alloxan-diabetic rabbits fed a low cholesterol diet.1984 · 36 citations
  5. 5Some Growth Factors Stimulate Cultured Adult Rabbit Ventricular Myocyte Hypertrophy in the Absence of Mechanical Loading1995 · 57 citations