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February 1, 1975Circulation Research

Effect of insulin on the proliferation of cultured primate arterial smooth muscle cells.

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Authors

RSR. W. StoutAssociation for Rural DevelopmentEBE L BiermanUnited States Department of Veterans AffairsRRRussell RossLiving Streets

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Implication

Randomized trial shows insulin stimulates smooth muscle cell growth in monkeys, indicating potential therapeutic implications.

Key Points

  • The study aims to investigate how insulin affects the growth of arterial smooth muscle cells from primates.
  • Smooth muscle cells were cultured from thoracic aortas of 1-year-old Macaca nemistrina.
  • Cells in culture were treated with varying concentrations of insulin and compared to controls.
  • Cell proliferation was assessed through statistical analysis of variance.
  • Insulin stimulated cell growth significantly at concentrations of 10 to 10,000 muunits/ml (P < 0.001).
  • The highest insulin concentration achieved 50% of the growth effect of 5% monkey serum.
  • Insulin's effect was inhibited by dibutyryl cyclic adenosine monophosphate (db-cAMP) after a latent period of three days.

Cite This Study

Stout et al. (1975) studied this question.

synapsesocial.com/papers/6a0808cd1e8b9db648ddeb07https://doi.org/10.1161/01.res.36.2.319
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Intra-arterial Insulin on Tissue Cholesterol and Fatty Acids in Alloxan-Diabetic Dogs1961 · 209 citations
  2. 2Inhibition of Cell Growth in vitro by Adenosine 3′,5′-Monophosphate1968 · 246 citations
  3. 3Development of Vascular Lesions in Insulin-treated Animals Fed a Normal Diet1970 · 78 citations
  4. 4Determination of the major constituents of small amounts of tissue1958 · 48 citations
  5. 5Lipoprotein Uptake and Metabolism by Rat Aortic Smooth Muscle Cells in Tissue Culture1974 · 486 citations