Population
Preclinical models including Xenopus oocytes expressing SK2 channels and mutant calmodulins, Escherichia…
Comparison
Mutations in calmodulin and SK2 alpha subunits vs Wild-type calmodulin and wild-type SK2 channels
Design
Preclinical
Authors
Loading...
Animal findings on CaM-SK2 gating warrant no clinical change; leaves open targeted SK modulation in human disease models.
Different domains of calmodulin are responsible for Ca2+-dependent and Ca2+-independent interactions with SK channels, with channel gating mediated by Ca2+ binding to the first and second E-F hand motifs.
Keen et al. (1999) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: