Population
Transfected cells expressing SK4/IK1 Ca2+-activated K+ channels
Comparison
Modulation of Calmodulin availability vs Control transfected cells
Design
Preclinical
Authors
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CaM regulates SK4 trafficking in this animal model; leaves open in vivo cardiac relevance or therapeutic targeting.
Calmodulin regulates the assembly and surface expression of SK4/IK1 Ca2+-activated K+ channels, revealing a novel mechanism for ion channel control.
Joiner et al. (2001) studied this question.
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